Study the Oxidant – Antioxidant Status in Acne Patients

Abstract

Background: Recent studies have suggested that ROS and oxidative stress are key players in the etiology of inflammatory acne lesions. H2O2 is an illustration of a ROS created by a neutrophil during phagocytosis, while malondialdehyde (MDA) is an illustration of a lipid peroxidation product. The state of oxidative stress and inflammation of the acne lesion are promoted by an imbalance of free radicals and antioxidants caused by excessive ROS production. Objective: The purpose of this study was to identify plasma levels of H2O2, MDA, superoxide dismutase, and catalase as potential acne risk factors. Methods: One hundred patients with Acne Vulgaris between the ages of 15 and 30 were included as cases. Prior to beginning treatment, individuals had their blood drawn. All participants in the cases and control groups gave written, informed consent after being told of the study's objectives. Result: Acne vulgaris patients' levels of MDA, H2O2, SOD and catalase were compared to control groups. The T test was used for statistical analysis. Conclusion: A risk factor for acne vulgaris includes blood plasma with high amounts of MDA, H2O2 and low levels of SOD, catalase.