Inflammatory Diseases of the Gastrointestinal Tract in Patients with Rheumotoid Arthritis: Topical Issues of Pathogenesis

Abstract

This review is devoted to the study of modern issues of the pathogenesis of inflammatory diseases of the gastrointestinal tract and rheumatoid arthritis. In the pathogenesis of inflammatory diseases of the gastrointestinal tract and rheumatoid arthritis, there are many similar links: the commonality of immune participants in inflammation and the forms of their interaction, the cellular composition of the inflammatory infiltrate of the gastrointestinal tract and the synovial membrane of the joints, the hyper production of pro-inflammatory cytokines and antibodies, the commonality of clinical manifestations.

Considering the mechanisms of the development of an immunoinflammatory reaction, it is necessary to point out the leading role of neutrophils and blood monocytes. The study of the functional activity of neutrophils and monocytes, which are directly involved in the development of inflammatory reactions and are the main components of inflammatory infiltrates of the intestinal wall and synovial membrane in inflammatory diseases of the gastrointestinal tract and rheumatoid arthritis, will help to better reveal the issues of their pathogenesis.