Laboratory and Molecular-Genetic Markers of the Progression of Non-Alcoholic Fatty Liver Disease (Literature Review And Own Data)
Keywords:
non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, cytokines, MBOAT7 gene, GCKR gene, cirrhosis, lipids, obesity.Abstract
Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in hepatology. First of all, this is associated with a high risk of progression of NAFLD with the development of non-alcoholic steatohepatitis (NASH), liver failure, and hepatocellular carcinoma. Epidemiological and genetic studies have shown the relationship between the morphological stage of NAFLD and hereditary factors. The article provides a review of the literature on the cytokines, MBOAT7 and GCKR genes. Also, a variant of the MBOAT7 and GCKR gene is associated with a high risk of fibrosis in patients with NAFLD and elevated serum triglyceride levels.
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